Nielsen Top Twenty Shows (18-49 Demo) for the week ending 09/28/08:
| Rank | Shows | Net | 18-49 Rating | 18-49 Viewers (000) |
| 1 | GREY'S ANATOMY-THU 9PM | ABC | 7.4 | 9,760 |
| 2 | DESPERATE HOUSEWIVES | ABC | 7.1 | 9,358 |
| 3 | NBC SUNDAY NIGHT FOOTBALL | NBC | 6.9 | 9,102 |
| 4 | DANCING WITH THE STARS | ABC | 5.3 | 7,052 |
| 5 | TWO AND A HALF MEN | CBS | 5.3 | 6,998 |
| 6 | CSI: MIAMI | CBS | 5.2 | 6,874 |
| 7 | HOUSE | FOX | 5.1 | 6,665 |
| 8 | HEROES | NBC | 5.0 | 6,619 |
| 9 | OT, THE | FOX | 4.9 | 6,532 |
| 10 | OFFICE | NBC | 4.9 | 6,479 |
| 11 | DANCING W/STARS SP-9/23(S) | ABC | 4.7 | 6,236 |
| 12 | Criminal Minds | CBS | 4.7 | 6,228 |
| 13 | BROTHERS & Sisters | ABC | 4.6 | 6,061 |
| 14 | Simpsons | FOX | 4.5 | 5,926 |
| 15 | SUNDAY NIGHT NFL PRE-KICK | NBC | 4.5 | 5,901 |
| 16 | SURVIVOR: GABON | CBS | 4.5 | 5,900 |
| 17 | Family Guy | FOX | 4.5 | 5,891 |
| 18 | FRINGE | FOX | 4.1 | 5,371 |
| 19 | HOW I MET YOUR MOTHER | CBS | 4.0 | 5,342 |
| 20 | CSI: NY | CBS | 4.0 | 5,233 |
Nielsen Ratings Data: ©2008 The Nielsen Company. All Rights Reserved
