Though I'm not yet sure it won't be a mid-season show NBC's The Cape goes immediately to the top of my list. Nothing says "fan favorite" and "bubble show" quite like Summer Glau. Firefly. Terminator: The Sarah Connor Chronicles. Heck, she even got in on the Dollhouse action briefly. While I'm rooting for Ms. Glau's show to be a hit for her sake, it goes to the top of the list.
Second on my list, and it's just a hunch right now is No Ordinary Family, the new show from ABC beginning this fall that follows a family with super hero powers.
I haven't seen the pilots, and of course have no ratings indicators yet, but those are my guesses. I'm not providing a list of new shows for the 2010-11 season here, though I will likely do that next week. We haven't stayed on top of all the pick-ups so far, but The Futon Critic, THR, Deadline and others have.